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1. Immunology Books Free Download Pdf
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Offer your patients the best possible care with clear, reliable guidance from one of the most respected and trusted resources in immunology. Authoritative answers from internationally renowned leaders in the field equip you with peerless advice and global best practices to enhance your diagnosis and management of a full range of immunologic problems.

Contents:
PART 1: Fundamental Principles of the Immune Response
1 The human immune response
2 Organization of the immune system
3 Innate immunity
4 Antigen receptor genes, gene products, and co-receptors
5 The major histocompatibility complex
6 Antigens and antigen processing
7 Antigen-presenting cells and antigen presentation
8 B-cell development and differentiation
9 T-cell development
10 Cytokines and cytokine receptors
11 Chemokines and chemokine receptors
12 Lymphocyte adhesion and trafficking
13 T-cell activation and tolerance
14 Programmed cell death in lymphocytes

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PART 2: Host Defense Mechanisms and Inflammation
15 Immunoglobulin function
16 Regulatory T cells
17 Helper T-cell subsets and control of the inflammatory response
18 Cytotoxic lymphocyte function and natural killer cells
19 Host defenses at mucosal surfaces
20 Complement and complement deficiencies
21 Phagocytes and phagocyte deficiencies
22 Mast cells, basophils and mastocytosis
23 Eosinophils and eosinophilia

PART 3: Infection and Immunity
24 Immune response to extracellular bacteria
25 Immune responses to intracellular bacteria
26 Immune responses to spirochetes
27 Immune responses to viruses
28 I mmune responses to protozoans
29 Immune responses to helminths

PART 4: Immunologic Deficiencies
30 Evaluation of the immunodeficient patient
31 Infections in the immunocompromised host
32 Development of the fetal and neonatal immune system
33 Aging and the immune system
34 Primary antibody deficiencies
35 Primary T-cell immunodeficiencies
36 Inherited disorders of IFN-?-, IFN-a/ß-, and NF-?B-mediated immunity
37 HIV infection and acquired immunodeficiency syndrome
38 Immunodeficiency due to congenital, metabolic, infectious,
surgical, and environmental factors

PART 5: Allergic Diseases
39 Pathogenesis of asthma
40 Management of the asthmatic patient
41 Rhinitis and sinusitus
42 Urticaria, angiodema, and anaphylaxis
43 Allergic reactions to stinging and biting insects
44 Atopic and contact dermatitis
45 Food allergy
46 Eosinophil-associated gastrointestinal disorders (EGID )
47 Allergic disorders of the eye
48 Drug hypersensitivity
49 Occupational and environmental allergic disorders

PART 6: Systemic Immune Diseases
50 Mechanisms of autoimmunity
51 S ystemic lupus erythematosus
52 Rheumatoid arthritis
53 Juvenile idiopathic arthritis
54 Sjögren’s syndrome
55 Systemic sclerosis
56 Inflammatory muscle diseases
57 Spondyloarthritis
58 Small- and medium-vessel primary vasculitis
59 Large-vessel vasculitides
60 Autoinflammatory fever syndromes
61 Antiphospholipid syndrome

PART 7: Organ Specific Inflammatory Disease
62 Immunohematologic disorders
63 Bullous diseases of the skin and mucous membranes
64 Myasthenia gravis
65 Multiple sclerosis
66 Autoimmune peripheral neuropathies
67 Immunologic renal diseases
68 Inflammation and atherothrombosis
69 Autoimmune thyroid diseases
70 Diabetes and related autoimmune diseases
71 Immunologic lung diseases
72 Sarcoidosis
73 Immunologic ocular disease
74 Immunologic disease of the gastrointesinal tract
75 Inflammatory hepatobiliary cirrhosis

PART 8: Neoplasia and the Immune System
76 Lymphoid leukemias
77 Lymphomas including Hodgkin lymphoma
78 Monoclonal gammopathies
79 Tumor immunology and immunotherapy

PART 9: Transplantation
80 Concepts and challenges in transplantation: rejection, immunosuppression and tolerance
81 Challenges and potentials of xenotransplantation
82 Hematopoietic stem cell transplantation for malignant diseases
83 Stem cell transplantation and immune reconstitution in immunodeficiency
84 Thymic reconstitution

PART 10: Prevention and Therapy of Immunologic Diseases
85 Immunoglobulin therapy: replacement and immunomodulation
86 Gene transfer therapy of immunologic diseases
87 Glucocorticoids
88 Nonsteroidal anti-inflammatory drugs
89 Antihistamines
90 Immunomodulating pharmaceuticals
91 Protein kinase antagonists as therapeutic agents for immunological
and inflammatory disorders
92 Vaccines
93 Immunotherapy of allergic disease
94 Cytokine therapy

Autor: Robert R. Rich
Editorial: S a u.n.d e r s
Edición: 4ª
Año: 2013
Páginas: 1095
ISBN: 978-0-7234-3710-9
Idioma: Inglés

Contraseña: booksmedicos.org

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Description

Janeway’s Immunobiology is intended for undergraduate and graduate courses and for medical students, but its depth and scope also make it a useful resource for trainees and practicing immunologists. Its narrative takes the host’s perspective in the struggle with the microbial world—a viewpoint distinguishing ‘immunology’ from ‘microbiology’. Other facets of immunology, such as autoimmunity, immunodeficiencies, allergy, transplant rejection, and new aspects of cancer immunotherapy are also covered in depth, and a companion book, Case Studies in Immunology, provides clinical examples of immunerelated disease. In Immunobiology, symbols in the margin indicate where the basic immunological concepts related to Case Studies are discussed.

The ninth edition retains the previous organization of five major sections and sixteen chapters, but reorganizes content to clarify presentation and eliminate redundancies, updating each chapter and adding over 100 new figures. The first section (Chapters 1–3) includes the latest developments in innate sensing mechanisms and covers new findings in innate lymphoid cells and the concept of ‘immune effector modules’ that is used throughout the rest of the book. Coverage of chemokine networks has been updated throughout (Chapters 3 and 11). The second section (Chapters 4–6) adds new findings for γ:δ T cell recognition and for the targeting of activationinduced cytidine deaminase (AID) class switch recombination. The third section (Chapters 7 and 8) is extensively updated and covers new material on integrin activation, cytoskeletal reorganization, and Akt and mTOR signaling. The fourth section enhances coverage of CD4 T cell subsets (Chapter 9), including follicular helper T cells that regulate switching and affinity maturation (Chapter 10). Chapter 11 now organizes innate and adaptive responses to pathogens around the effector module concept, and features new findings for tissue-resident memory T cells. Chapter 12 has been thoroughly updated to keep pace with the quickly advancing field of mucosal immunity. In the last section, coverage of primary and secondary immunodeficiencies has been reorganized and updated with an expanded treatment of immune evasion by pathogens and HIV/AIDS (Chapter 13). Updated and more detailed consideration of allergy and allergic diseases are presented in Chapter 14, and for autoimmunity and transplantation in Chapter 15. Finally, Chapter 16 has expanded coverage of new breakthroughs in cancer immunotherapy, including ‘checkpoint blockade’ and chimeric antigen receptor (CAR) T-cell therapies.

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End-of-chapter review questions have been completely updated in the ninth edition, posed in a variety of formats, with answers available online. Appendix I: The Immunologist’s Toolbox has undergone a comprehensive revitalization with the addition of many new techniques, including the CRISPR/Cas9 system and mass spectrometry/ proteomics. Finally, a new Question Bank has been created to aid instructors in the development of exams that require the student to reflect upon and synthesize concepts in each chapter.

Once again, we benefited from the expert revision of Chapter 12 by Allan Mowat, and from contributions of two new contributors, David Chaplin and Leslie Berg. David’s combined clinical and basic immunologic strengths greatly improved Chapter 14, and Leslie applied her signaling expertise to Chapters 7 and 8, and Appendix I, and her strength as an educator in creating the new Question Bank for instructors. Many people deserve special thanks. Gary Grajales wrote all end-of-chapter questions. New for this edition, we enlisted input from our most important audience and perhaps best critics—students of immunology- in-training who provided feedback on drafts of individual chapters, and Appendices II–IV. We benefitted from our thoughtful colleagues who reviewed the eighth edition. They are credited in the Acknowledgments section; we are indebted to them all.

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We have the good fortune to work with an outstanding group at Garland Science. We thank Monica Toledo, our development editor, who coordinated the entire project, guiding us gently but firmly back on track throughout the process, with efficient assistance from Allie Bochicchio and Claudia Acevedo-Quiñones. We thank Denise Schanck, our publisher, who, as always, contributed her guidance, support, and wisdom. We thank Adam Sendroff, who is instrumental in relaying information about the book to immunologists around the world. As in all previous editions, Matt McClements has contributed his genius—and patienc —re-interpreting authors’ sketches into elegant illustrations. We warmly welcome our new text editor Elizabeth Zayetz, who stepped in for Eleanor Lawrence, our previous editor, and guiding light. The authors wish to thank their most important partner —Theresa and Cindy Lou—colleagues in life who have supported this effort with their generosity of time, their own editorial insights, and their infinite patience.

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As temporary stewards of Charlie’s legacy, Janeway’s Immunobiology, we hope this ninth edition will continue to inspire—as he did—students to appreciate immunology’s beautiful subtlety. We encourage all readers to share with us their views on where we have come up short, so the next edition will further approach the asymptote. Happy reading!

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Kenneth Murphy
Casey Weaver